marți, 1 martie 2011

STEM CELLS

Are cells that are at the initial stage of cell development. Embryo develops from a single cell that
begins to multiply. The first cells are identical and only later will specialize turning into different
cell types that make up the various tissues of the body. These stem cells can turn into any tissue
type desired.
Because stem cell capacity to transform into any desired cell type scientists trying to obtain these
cells in several ways and their implantation in tissue weakened. in order to regenerate the
area. Can be used in heart disease, diabetes, Parkinson's, etc.. One way of obtaining stem cells
by cloning. German researcher Kansai Spemann issue in 1938 the theory that cloning was
possible starting from the nucleus of a cell of an individual who was inserted into an egg whose
own first nucleus is removed. Cloning is the beginning and present difficulties. It took 484
embryos to be cloned sheep Dolly was born and 84 for mouse Cumulina.
From these eggs have replaced the nucleus of adult somatic cells. Egg which is now complete
genetic code (DNA double chain) behave like a fertilized egg and kept in culture medium under
conditions appropriate chemical stimulation begins to divide and multiply. With stem cells are
obtained various cell types of tissues, skin, nerve, retina, smooth muscle, bone, cartilage,
connective tissue, etc.. The next step would have been transplanted tissues in patients. It
replaced the egg nucleus with a nucleus of a somatic cell taken from a patient who wants stem
cell transplantation. Replacement occurs because stem cells results. have the same DNA in the
nucleus, thus wishing to that transplanted stem cells be compatible with the patient and decrease
the chances of being rejected by the body. Yet there is danger of being rejected because besides
kernel of the same patient's DNA that has been transplanted cells, cell rest has another gene
construction.
Italian researcher Angelo Vescovi demonstrated experimentally that nerve cells can be
transferred into cells hematite thus opening a new field of research. Today treatment with stem
cells is performed with the patient's own stem cells harvested from bone marrow avoiding any
rejection. A diabetic which will be injected their own stem cells in the pancreas, they will turn into
pancreas cells and heal the person with diabetes. The cornea will be injected into cells that make
up the cornea, regenerating it, people being healed.
Dr Amit Patel from Mc Gowan Institute of Regenerative Medicine in Pittsburgh performed
bypass coronary on twenty patients with severe heart failure. Half of them were taken from bone
marrow of the pelvis two types of stem cells which were injected into the heart during
surgery. University announced that after six months left ventricle of the heart that pushes blood
increased by 24% its thrust. Dr. Amit Patel said: "one of these patients could not work at all and
now are returning to work. Are very promising results. Stem cells injected into heart muscle cells
turn into new heart and new blood vessels.
A report conducted by the Discovery Television presented the cases of older people with serious
cardiac deficiencies after they were injected into muscle tissue of the heart stem cells which had
been harvested from bone marrow have returned can run several miles daily.
Another experiment: a few mice were removed a portion of the spine spinal nerve leaving them
paralyzed. After those were implanted stem cells in place were implanted special fibers which
were coated with stem cells (as cotton absorbs water) so that the stem cells to restore spinal
nerve connections between the ends of the spine, namely replacing the missing portion. Stem
cells turned into nerve cells and mice began to walk without sequelae remains. Stem cell
treatment is the best option being transplanted into their body cells that have the same genetic
construction.
In organ transplantation they have different genetic construction and the body rejects the
transplanted organ, namely the immune system attacks and destroys cells transplanted
considering them enemies because of different genetic structure of the host body.
Man must take rest of life immunosuppressants, drugs that block the immune system and leaves
the body discovered before the disease. Anyway man lives after a transplant usually a very short
time. For someone to receive an organ someone else must die. When an individual who needs a
transplant has a good financial standing and is willing to pay, the situation is resolved. Specifically
someone is killed. Melatonin
Melatonin is a hormone secreted by glands located in the brain epiphysis.
Dr. Randy Nelson of Johns Hopkins University in Baltimore has taken a number of mice that has
divided into two groups. In both groups gave carcinogens only difference being that one group
was kept in an environment with low light (winter) while the other group was kept in bright light
(summer). 85% of mice kept in bright light of summer have cancer while none of the mice kept in
low light (winter) were not sick.

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